George (Russell Tovey) and Mitchell (Aiden Turner) work in anonymous drudgery as hospital porters in Bristol, England. They lead lives of quiet desperation under the burden of a terrible secret - Mitchell's a vampire and George a werewolf. Deciding to start a life afresh and leave behind the dark side, they move into a house, only to find that Annie (Lenora Crichlow), the ghost of a woman killed in mysterious circumstances, haunts it. As the threesome deal with the challenges of their new lives together, they're united in their desire to blend in with their human neighbors. But with unwelcome intruders into their world, a threatened revolution from the vampire underworld, constant threats of exposure, and the day-to-day issues faced by young people, the only thing they may be able to rely on is each other.